BIOTA Philippines Conference System, 52nd BIOTA Annual National Convention and Scientific Sessions

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HEPATOPROTECTIVE PROPERTY OF “CRATOXYLON SUMATRANUM” ON LIVER DAMAGE CAUSE BY PARACETAMOL IN RATS
Belinda Dagaas Gabionza

Last modified: 2017-03-13

Abstract


Ethanolic extract of Cratoxylon sumatranum (Paguringon) was evaluated for hepatoprotective property in rats. The plant extract (500mg/kg BW) showed a remarkable hepatoprotective property against paracetamol induced hepatotoxicity as judged from the serum markers for liver damage. Paracetamol induced a significant rise in aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Treatment of rats with ethanol extract (500mg/kg BW) significantly altered serum marker enzymes levels to near normal against paracetamol treated rats. The activity of the extract was comparable to the standard hepatoprotective drug (Silymarin, 600mg/g BW). These biochemical observations were in turn confirmed by histopathological examination of liver sections. Results indicate that Cratoxylon sumatranum possesses hepatoprotective effect on paracetamol induced hepatotoxicity in rats.

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